Sylvain Moineau Ph.D.
Professeur titulaire

Département de biochimie, de microbiologie et de bio-informatique
Faculté des sciences et de génie
Pavillon Alexandre-Vachon
1045 avenue de la Médecine, Université Laval
Québec, Canada, G1V 0A6
Tel: 418 656-3712
Fax: 418 656-2861
Courriel: sylvain.moineau@bcm.ulaval.ca

Welcome on Sylvain Moineau's laboratory website

In our laboratory, we are studying bacteriophages (or phages).

It is now recognized that phages are the most abundant biological entities on the planet. These viruses specifically infect bacteria. They are found in the same enviroments as their bacterial hosts and play a key role in maintaining the balance of ecosystems. Phages are also excellent viral models applicable to various research areas.

Bacteriophages can be both friends and foes. Friends since they suppress bacterial populations with harmful properties, including pathogenic bacteria. These phages can have industrial and medical applications as biocontrol agents. Foes because they can destroy bacteria that play an important role in food fermentations.

Our main goal is to increase knowledge of phage biology. We favor an integrative approach (combining data from genomics, transcriptomics, proteomics, and structural biology) to understand the interactions between phages and bacteria. New tools are also developed to remove bacteriophages in dairy fermentations and to favor their use as antibacterial agents in various industrial sectors and public health.

To know more about our research projects, visit this website (In French): Research

Our laboratory also houses the largest public collection of bacteriophages in the world (www.phage.ulaval.ca).

Recent publications

News

Fraud, S., and S. Moineau. 2018. Phages. Le fromage. 4ième édition. J.-C. Gillis and A. Ayerbe (eds). Lavoisier. p. 293-302. Abstract

Lévesque, S., and S. Moineau. 2018. A stockpile of antiviral defences. Nature. 556:318-319. Abstract

Mottawea, W., M.-O. Duceppe, A.A. Dupras, V. Usongo, J. Jeukens, L. Freschi, J.-G. Emond-Rheault, J. Hamel, I. Kukavica-Ibrulj, B. Boyle, A. Gill, E. Burnett, E. Franz, G. Arya, J.T. Weadge, S. Gruenheid, M. Wiedmann, H. Huang, F. Daigle, S. Moineau, S. Bekal, R.C. Levesque, L. Goodridge, and D. Ogunremi. 2018. Salmonella enterica prophage sequence profiles reflect genome diversity and can be used for high discrimination subtyping. Front. Microbiol. Abstract

Vincent, C., V. Usongo, C. Berry, D.M. Tremblay, S. Moineau, K. Yousfi, F. Doualla-Bell, E. Fournier, C. Nadon, L. Goodridge, and S. Bekal. 2018. Comparison of advanced whole genome sequence-based methods to distinguish strains of Salmonella enterica serovar Heidelberg involved in foodborne outbreaks in Québec. Food Microbiol. 73:99-110. Abstract

Lemay, M.-L., A.C. Renaud, G.M. Rousseau and S. Moineau. 2018. Targeted genome editing of virulent phages using CRISPR-Cas9. Bio-Protocol. 8: e2674. Abstract

Geagea, H., S.J. Labrie, M. Subirade and S. Moineau. 2018. The tape measure protein is involved in the heat stability of Lactococcus lactis phages. Appl. Environ. Microbiol. 84:e02082-17. Abstract

Vincent, A.T., F.D. Rouleau, S. Moineau, and S.J. Charrette. 2017. Study of mesophilic Aeromonas salmonicida A527 strain sheds light on the species lifestyles and taxonomic dilemma. FEMS Microbiol. Lett. 364:fnx239. Abstract

Weissman, J.L., R. Holmes, R. Barrangou, S. Moineau, W.F. Fagan, B. Levin, and P.LF. Johnson. 2018. Immune loss as a driver of coexistence during host-phage coevolution. ISME J. 12:585-597. Abstract

de Melo, A.G., S. Levesque, and S. Moineau. 2018. Phages as friends and enemies in food processing. Curr. Opin. Biotechnol. 49:185-190. Abstract

Hynes, A.P., G.M. Rousseau, M.L. Lemay, P. Horvath, D.A. Romero, C. Fremaux, and S. Moineau. 2017. An anti-CRISPR from a virulent streptococcal phage inhibits Streptococcus pyogenes Cas9. Nat. Microbiol. doi: 10.1038/s41564-017-0004-7. Abstract

Vincent, A.T., V.E. Paquet, A. Bernatchez, D.M. Tremblay, S. Moineau, and S.J. Charette. 2017. Characterization and diversity of phages infecting Aeromonas salmonicida subsp. salmonicida. Sci. Rep. 7:7054. Abstract

Kot, W., M. Sabri, H. Gingras, M. Ouellette, D.M. Tremblay, and S. Moineau. 2017. Complete Genome Sequence of Streptococcus pneumoniae Virulent Phage MS1. Genome Announc. 5:e00333-17. Abstract

Emond-Rheault et al. 2017. A Syst-OMICS Approach to Ensuring Food Safety and Reducing the Economic Burden of Salmonellosis. Front. Microbiol. 8:996. Abstract

Lemay, M.L., P. Horvath, and S. Moineau. 2017. The CRISPR-Cas app goes viral. Curr. Opin. Microbiol. 37:103-109. Abstract

Eraclio, G., M. G. Fortina, S. J. Labrie, D. M. Tremblay, and S. Moineau. 2017. Characterization of prophages of Lactococcus garvieae. Sci. Rep. 7:1856. Article

Lemay, M.L., D.M. Tremblay, and Moineau. 2017. Genome engineering of virulent lactococcal phages using CRISPR-Cas9. ACS Synth. Biol. Abstract

Hynes, A.P., and S. Moineau. 2017. Phagebook: The Social Network. Mol. Cell 65:963-964. Abstract

Achigar, R., A.H. Magadan, D.M. Tremblay, M. Julia Pianzzola, and S. Moineau. 2017. Phage-host interactions in Streptococcus thermophilus: Genome analysis of phages isolated in Uruguay and ectopic spacer acquisition in CRISPR array. Sci. Rep. 7:43438. Abstract

Geagea, H., A. Gomaa, G. Remondetto, S. Moineau, and M. Subirade. 2017. Molecular structure of lactoferrin influences the thermal resistance of lactococcal phages. J. Agric. Food Chem. 65:2214-2221. Abstract

Trudel, L., M. Frenette, S. Moineau. 2017. CRISPR–Cas in the laboratory classroom. Nat. Microbiol. 2:17018. Résumé

Hynes, A.P., M.-L. Lemay, L. Trudel, H. Deveau, M. Frenette, D.M. Tremblay et S. Moineau. 2017. Detecting natural adaptation of the Streptococcus thermophilus CRISPR-Cas systems in research and classroom settings. Nat. Protoc. Résumé

Moineau, S. et D.M. Tremblay. 2017. Bacteriophage. Reference Module in Life Sciences. Pages 1-5. doi:10.1016/B978-0-12-809633-8.06122-7. Résumé

Hamdi, S., G.M. Rousseau, S.J. Labrie, D.M. Tremblay, R. Saïed Kourda, K. Ben Slama et S. Moineau. 2017. Characterization of two polyvalent phages infecting Enterobacteriaceae. Sci. Rep. Résumé

Champagne, C.P., S. Moineau, S. Lafleur et T. Savard. 2017. The effect of bacteriophages on the acidification of a vegetable juice medium by microencapsulated Lactobacillus plantarum. Food Microbiol. 63:28-34. Résumé


See all the publications

Mai 2018

Congrats Moïra!

April 2018

FSG (In French)

Le Soleil (In French)

Congrats Rachel!

Le Fil (In French)

December 2017

Officer of the Order of Canada

CHU de Québec (In French 

Le Fil (In French)

CRISPR: Swiss army knife (In French)

November 2017

Highly cited researcher 2017

Journal de Québec In French

UL Press release (In French) 

Le Fil (In French)

October 2017

CRISPR 2019 - Le Soleil (In French)

La guerre des micromondes (In French)

September 2017

Royal Society of Canada

Le Soleil (In French)

Le Fil (In French)

August 2017

CRISPR: Radio-Canada (In French)

CRISPR: Le Soleil (In French)

Juillet 2017

Dupont Medal

June 2017

Bravo Alex !
Bravo Félix !

May 2017

CSM Murray Award

360 PM - Chronique sciences (In French)

April 2017

Bravo Moïra !

Bravo Marie-Laurence !

March 2017

Pub in Le Devoir

CHR - Researcher of the Month

Le Fil (In French)
From research to teaching

February 2017

NSERC John C. Polanyi Award

Video (English subtitles)

Photos

FSG - News (In French)

UL - Press release (In French)

The Globe and Mail

Le Soleil (In French)

Le Fil (In French)

CRISPR: Science Borealis Blog

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(Dernière mise à jour,20 May 2018)
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